News
Quatrefolic® Takes Center Stage in Next-Generation Prenatal Nutrition
18 September 2026
The growing focus on active folate is reshaping the prenatal supplement landscape, with innovative formulations increasingly turning to 5-MTHF as a direct source of biologically active folate.
Redefining Quality and Innovation, Supporting Prenatal Nutrition
At the heart of this evolution is Quatrefolic®, the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF), the metabolically active form of folate. Unlike folic acid, 5-MTHF provides folate in a form the body can use directly, without requiring the same conversion process.
But Quatrefolic®‘s value goes beyond its active form. Its high water solubility, long-lasting stability, and controlled GMP manufacturing support consistent quality and formulation flexibility. Gnosis by Lesaffre has also conducted comparative studies investigating its bioavailability versus the old-generation compound.
The growing adoption of active folate in prenatal products signals a broader industry shift: from simply delivering folate to selecting the right form, quality, and performance of the ingredient.
Quatrefolic® continues to lead this evolution, offering formulators an advanced active folate solution for next-generation nutritional products.
