What is Quatrefolic®?

Quatrefolic® represents an innovative dietary ingredient designed to act as a nutrient in all areas where folic acid and supplementation has been recommended and allowed. The terms folic acid and folate are often used interchangeably for the water-soluble B-complex vitamin, essential for the maintenance of cellular functions and health.

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid. Developed by Gnosis By Lesaffre it represents the fourth generation folate compared to 5-methyltetrahydrofolate calcium salt guaranteeing an improved bioavailability.

Quatrefolic®: A choice that makes the difference

Choosing Quatrefolic® as a source of folate presents several advantages both for manufacturer of food and feed ingredients and for the consumer of supplements and food products:

  • Provides the active form of folate, 5-methyltetrahydrofolate, naturally present in the body and available for its biological action.

  • Has been recognized GRAS. Gnosis by Lesaffre has undertaken several in vitro and in-vivo preclinical and clinical studies to characterize and guarantee the safety profile of the product.

  • Is a Gnosis by Lesaffre proprietary product with patents and trademark applications guaranteeing a wide range of use and covering all areas of folate application.

  • Is produced according to cGMP, guaranteeing a reproducible quality profile.

  • Glucosamine, as a salt of (6S)-5-methyltetrahydrofolate, does not come from animal sources and the product is suitable for vegetarian consumption.

  • Higher bioavailability and improved water solubility shown by Quatrefolic® respect to calcium salt, open new perspectives and uses for combinations and formulations with vitamins and minerals, both for dietary supplements and Food & Beverage industry.

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