Quatrefolic®, homocysteine, and cognitive function.
Hyperhomocysteinemia (HHcy) is widely considered a powerful risk factor for the development and progression of cognitive decline, dementia, and Alzheimer’s disease.
An increase in homocysteine levels indicates the functional status of three B vitamins: folate, B12, and B6. As we age, we may become more susceptible to vitamin B deficiencies due to natural declines in absorption rates, inadequate nutrient intake, drug interactions, or genetic polymorphisms.
Quatrefolic® supplemetation can:
• Lower/normalize Hcy
• Sustain GSH production, the master antioxidant to fight neuroinflammation
• Optimize the response to oxidative stress, lowering inflammation and sustaining gene expression.
Quatrefolic®: Do Not Mask the Effect of Vitamin B12
Vitamin B12 deficiency is a prevalent concern, particularly in elderly populations and individuals who follow vegetarian diets. Low vitamin B12 status is linked to a higher incidence of anemia and cognitive impairment.
Adapted from Morris 2007: “Folate and vitamin B-12 status about anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification” Moore E.M. et al. J Alzheimers Dis. 2014; Morris M.S. J Clin Nutr. 2007; Selhub J. et al. Am J Clin Nutr. 2009; Smith A.D. Am J Clin Nutr. 2007
Folic acid supplementation may activate purine and pyrimidine synthesis through a specific pathway correcting anaemia, although vitamin B12 is still absent; on the contrary, nerve and cognitive deterioration related to vitamin B12 deficiency may continue unchecked.
Quatrefolic® supplementation does not activate purine and pyrimidine synthesis, and if vitamin B12 is absent, 5-MTHF remains “metabolically trapped.” This situation produces a “pseudo folate deficiency” because although the cells have adequate folate levels, they are trapped as 5-MTHF, allowing doctors to diagnose vitamin B12 deficiency.
