In 2050, the over 60 years will represent 22% of the world’s population. As aging comes with new challenges for us bodies, this reality implies an increase in health needs.

Dietary deficiencies, Vitamin D, Magnesium, Calcium, and vitamin B are often prevalent in the elderly. Studies show that approximately 30% of individuals aged ≥ 65 years old experience a deficiency of folate. Notable works, done in healthy aging, have focused on ingredients that reduce oxidative stress (such as active folate) and consequences in health. They suggest that some ingredients could also be related to immunity. Indeed, poor folate levels are associated with an increased risk of diseases which may imply hyperhomocysteinemia, vascular issues, and cognitive dysfunction.



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What does folate do for the brain?

Thanks to its various health claims (EFSA APPROVED) related to psychological functions, reduction of tiredness and fatigue, cell division, normal homocysteine metabolism, and well function of the immune system, folate is a good solution for elderly people.

For older adults and the elderly, the supplementation of the proper form of folate is essential to quickly re-establish the plasma folate levels and counter the variety of physiologic changes that influence folate status and the need for medical care.

In 2000, Bottiglieri and Reynolds showed that the concentration of folate in the cerebrospinal fluid (CSF) decreases with age, particularly in older adults over 70 of age. This provided further evidence of a link between folate concentration and age, and for the first time, highlighted this connection directly in the nervous system.

Quatrefolic® supplementation is suggested to guarantee the right dosage of biologically active folate and to efficiently support brain function since it is the only folate form able to cross the blood-brain barrier.

Bottiglieri T., Reynolds E. et al. J Neurol Neurosurg Psychiatry 2000
Seshadri S. at al. N Engl J Med 2002
Stover PJ et al. Curr Opin Biotechnol. 2017
Rima Obeid R., Herrmann W. FEBS Letters 580, 2006

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