Quatrefolic^® Advantages vs. Folic Acid

To become biologically active, folic acid needs to go through several transformation steps in the body.

During the multi-step process, biologically inactive folic acid is converted into the biologically active form of folate called 5-methyltetrahydrofolate (5-MTHF), which is utilized by our bodies. This process involves utilizing a different enzyme for every step.

However, some individuals have a genetic trait known as MTHFR polymorphism that inhibits them from producing adequate levels of the MTHFR enzyme. As the critical final step in the conversion process, the deficiency of the MTHFR enzyme results in a diminished capacity to convert inactive forms of folate and folic acid into the biologically active form of folate referred to as 5-MTHF.

As the next-generation solution that bypasses the need for the bioconversion of folic acid in the body, 5-MTHF functions as a nutrient in all applications where folic acid and active folate supplementation are recommended.

Quatrefolic^® is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced and active form of folate found in our bodies.