Quatrefolic^® the active folate & pregnancy outcome vs folic acid

6 July 2018

A recently published case series study has evaluated the effect of 5-MTHF glucosamine salt (Quatrefolic^®) in couples with recurrent miscarriages, lasting for at least 4 years.

5-MTHF glucosamine salt (Quatrefolic^®) has been supplemented in a B vitamin complex and chelated zinc (Impryl^®, Parthenogen, Switzerland or Tretrafolic^®, Nurilia, France) at the dosage of 800 µg/day, according to the 5-MTHF glucosamine salt requirements in healthy women.

Of 33 couples, 13 spontaneous pregnancies were observed at the end of the treatment and other 13 pregnancies were obtained after Assisted Reproductive Technology (ART), with the overall ongoing pregnancy rate of 86.7%.
The study conclusion highlights that the conventional use of large doses of folic acid (5 mg/day) has become obsolete. A physiological dose of 5-MTHF glucosamine salt (800 μg) bypasses the MTHFR block and is suggested to be an effective treatment for couple fertility problems.

The study highlights the benefits of Quatrefolic^®– the active folate form immediately bioavailable without metabolization of MTHFR enzyme – and the importance of scientific communication led by Gnosis in these years.
Finished formulations with Quatrefolic^® are in the limelight of new clinical studies, providing even more evidence of the advantages with respect to the folic acid, in terms of efficacy and safety.

Ref: Servy, E.J., Jacquesson-Fournols, L., Cohen, M. et al. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. J Assist Reprod Genet 2018.