Quatrefolic 360° collection: Folate and Fertility

Globally, not less than 48 million to 186 million  individuals have a fertility issue. Recently, studies have highlighted the importance of folate level and homocysteine status as critical factors in the early stages of human reproduction.

How folate is correlated to fertility?

Women and men experiencing fertility issues can present low folate availability, often linked to the MTHFR enzyme polymorphism.
Preconceptionally folate supplementation seems to have positive reproductive outcomes in natural pregnancies and pregnancies after assisted reproductive technology (ART) treatment.

In women, inadequate folate levels increase homocysteine levels in the blood. and oxidative stress, one of the factors related to the pathogenesis of fertility disorders such as idiopathic infertility, polycystic ovarian syndrome, and endometriosis.
In men, folate is essential for spermatogenesis. Low folate levels in semen can be associated with poor sperm stability and DNA damage.

Quatrefolic^® the right choice of folate

Thanks to its bioavailability that bypasses the MTHR polymorphism, Quatrefolic^® provides the adequate folate dosage. It does not require the metabolism of the MTHFR enzyme and is ready to enter human metabolism to normalize homocysteine plasma levels.