Folate Shows Promise for Mood

Emerging research highlights the potential benefits of folate supplementation in reducing symptoms of depression, particularly when used alongside traditional antidepressant treatments.

Folate, a B vitamin essential for brain function, is critical in producing neurotransmitters such as serotonin, dopamine, and norepinephrine—chemicals often linked to mood regulation. 

Are Folate and Folic Acid the Same?

Three primary forms of folate are used in supplementation: folic acid, 5-methyltetrahydrofolate (5-MTHF), and folinic acid. Some of these, particularly 5-MTHF, may offer better absorption and effectiveness, especially in individuals with genetic variations. 

Quatrefolic^® doesn’t need metabolic conversion steps in the body.  

It is bioavailable for everyone, including groups with MTHFR polymorphism.​ 

Vitamin B12 Deficiency and Folate’s Role

Clinical studies indicate that folate can help reduce lingering symptoms in people with depression. The 5-MTHF form, in particular, has shown promise as a standalone option and in combination with other therapies. It has been associated with improvements in cognitive function and mood in elderly patients with dementia and folate deficiency, as well as in individuals with depression complicated by alcohol use. 

Most studies have focused on folic acid; however, folate supplements appear well tolerated overall. The 5-MTHF variant may carry fewer risks than traditional folic acid, including a lower likelihood of masking vitamin B12 deficiency. 

Quatrefolic^® is unlikely to mask vitamin B12 and its hematologic symptoms, as the pathway where it is involved is vitamin B12-dependent.