ConsumerLab seals of approval for supplements with folate

DESIO, Italy - October, 24th 2016

The importance of the consumption of folate to support the body's well-being is now widely recognized and folate definitely represents one of the most common nutritional ingredients used during all stages of life.

Very recently ConsumerLab has published a new report title "B Vitamin Supplements and Energy Drinks (Including B Complexes, Niacin, B-6, B-12, Biotin, Thiamin, and Folate)" where several finished dietary supplements, commercialized in the US market and containing the (6S)-5-methyltetrahydrofolate (5-MTHF) - the biological active form of folate - or folic acid, have been tested.

With a long history of certifying supplement, ConsumerLab is the leading provider of independent test results and information to help consumers and healthcare professionals to identify the best quality health and nutrition products.

The report mentions the rational use of reduced folate and describes why they are suggested for people with a gene polymorphism of the enzyme MTHFR (methyltetrahydrofolate reductase) that drives to an impairment in the metabolization of folic acid from food or supplements.

The report highlights the results for products containing one or more B vitamins. Supplements with the vitamin B9 (folate) were stand alone or in combination with other ingredients. Among these, all those formulated with the biologically active reduced folate 5-MTHF contain Gnosis ingredients, and 66% of these counts the glucosamine salt Quatrefolic®. All supplements with Gnosis' ingredients passed the ConsumerLab tests.


Aberrant folate metabolism has adverse effects on human health, including increased risk for birth defects, cancer, cardiovascular disease, end-stage renal disease, diabetic neuropathy, and CNS disorders such as depression and cognitive impairment. Among folate, Quatrefolic®, the Gnosis' proprietary innovActive folate made up of the glucosamine salt of (6S)-5-MTHF, is even more recognized as the folate of reference in the US market, as a direct source of the 5-MTHF that doesn’t need to be metabolized and can enter immediately folate-dependent pathways. It has established itself as the benchmark for the whole industry of folate derivatives.

The independent prove of the stability of Quatrefolic® in supplements, together with the already known advantages of this recommended reduced folate demonstrate again like it is a winning mix of efficacy, innovation and safety.


Since the phase of development Gnosis has deliberately chosen to carry out stringent stability test on Quatrefolic® performed according to ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guidelines specifically required for pharmaceutical ingredients guaranteeing undependable and reliable criteria to claim the long lasting chemical stability to its clients. Quatrefolic® shows a long lasting chemical stability at both room and refrigerated conditions, guaranteeing purity and ensuring easy handling and storage.

Stability at room temperature might be a useful indicator to predict shelf life especially for combining the Quatrefolic® with other components such as vitamins and minerals.

Ask for the WHITE PAPER to know all about Quatrefolic®