Many studies have linked the presence of MTHFR polymorphisms and hyperhomocysteinemia with unfavorable health outcomes such as cardiovascular diseases, neonatal defects, recurrent pregnancy loss, neural tube defects, preterm and low birth weight, gestational diabetes, and the risk of preeclampsia, postpartum psychopathology, osteoporosis.
What are the effects of MTHFR polymorphisms in menopausal women?
The onset of natural menopause before the expected age is linked to a higher risk of health issues like cardiovascular diseases, osteoporosis, ovarian, breast, and endometrial cancer. It has been suggested that MTHFR polymorphism could be a determining factor in the onset of early natural menopause.
This genetic variation might contribute to the negative health effects experienced during menopause, primarily because it impacts the plasma homocysteine level.
Studies indicate that plasma homocysteine levels significantly increase following menopause, which may explain the connection between MTHFR polymorphism and health concerns encountered during menopause.
MTHFR polymorphisms have also been associated with osteoporosis, the risk of depression, and the metabolic syndrome in post-menopausal women.
The active folate, such as Quatrefolic®, can reduce and normalize the homocysteine level and attenuate these risks improving the health of menopausal women.