Hot flashes are among the most common vasomotor symptoms of menopause (VMS) and affect up to 74% of perimenopausal women. As suggested by clinical studies, the severity and frequency of hot flashes and night sweats may decrease thanks to active folate supplementation, such as Quatrefolic®.
The exact pathogenesis of hot flashes is unknown, but studies indicate that the menopausal vasomotor symptoms result from a defect in central thermoregulatory functions. These vasomotor symptoms are modulated by different hormones and neurotransmitters, especially estrogen. The withdrawal of estrogen from the ovaries is the initial mechanism leading to hot flashes.
Norepinephrine and serotonin also play a role in the modulation of the thermoregulatory setpoint and the normalization of the thermoregulatory response.
Folate is a building block in the synthesis of monoamine neurotransmitters (serotonin, dopamine, noradrenaline) and S-adenosylmethionine (SAMe), which contribute to the synthesis of the former.
Therefore, active folate supplementation, such as Quatrefolic® may help to reestablish neurotransmitter synthesis in cases of estrogen deficiency during menopause and to normalize the thermoregulatory response.
 Rapkin AJ. Vasomotor symptoms in menopause: physiologic condition and central nervous system approach to treatment. Am J Obstet Gynecol. 2007 Feb;196(2):97-106.