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New Study About Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in Pregnancy
6 November 2025
A new study published in The Journal of Nutritional Biochemistry explores how obesity-related inflammation affects iron deficiency (ID) during pregnancy. The study also emphasized the crucial role of folates, such as Quatrefolic®, which may play a key role in mitigating some of the negative effects associated with iron deficiency.
Both obesity and iron deficiency (ID) are major global health concerns that can lead to complications for mothers and infants. Conducted by researchers from the University of Ulster, this study analyzed data from 125 pregnant women in a clinical trial, highlighting a health issue that affects millions of women worldwide.
Obesity and Inflammation: A Dual Risk for Pregnancy
The analysis showed that women with obesity during pregnancy have elevated levels of systemic inflammation, which can interfere with the absorption and utilization of iron. Iron deficiency is a common issue during pregnancy, with consequences ranging from chronic fatigue to more severe complications, such as premature birth and low birth weight. The combination of maternal adiposity and inflammation can exacerbate these risks, creating a cycle of adverse effects that impact both the mother and the baby.
The Crucial Role of Folates in Combating Iron Deficiency
In this context, folates are an essential nutrient. Folates are recognized for their significance in DNA synthesis and red blood cell production, making them vital in combating and treating iron deficiency anemia. The study suggests that a sufficient intake of folate may enhance iron absorption, thereby reducing the risks associated with iron deficiency.
Furthermore, folates also help reduce inflammation. This anti-inflammatory property could be especially helpful for pregnant women with high inflammation levels caused by obesity, aiding in regulating the inflammatory response and supporting a healthier uterine environment.
Benefits for Maternal Health and Fetal Development
Besides stopping anemia, folates are essential for supporting fetal neural tube development, which in turn reduces the risk of congenital disabilities. Folate supplementation, therefore, can not only help improve iron levels but also promote healthier pregnancies and better outcomes for the baby.
This study highlights the importance of optimal nutritional management during pregnancy, particularly for women with obesity, to ensure adequate levels of iron and folate, such as Quatrefolic®.
