New Evidence on Folate Deficiency as a Risk for Hypertension

The Importance of Managing Folate Deficiency

Folate deficiency remains a common nutritional issue worldwide, and in severe cases, it can lead to various clinical abnormalities, including macrocytic anemia, carcinogenesis, and cardiovascular diseases.  

Folate plays a crucial role in vascular function, and low levels may contribute to endothelial dysfunction and impaired blood pressure regulation. 

Quatrefolic®, the active form of folate, maintains the proper level of folate to avoid the risk of deficiency.   

The Relationship Between Folate Levels and Hypertension

An extensive cross-sectional and cohort study conducted by Zhang et al. analyzed data from nearly 500,000 participants to examine the relationship between folate and hypertension. Among 200,000 individuals without hypertension at the start, 18,000 developed over a median follow-up of 12.8 years.   

Participants with folate deficiency had a 42% higher risk of developing hypertension compared to those with adequate folate levels. 

These findings were further supported by genetic analyses, which indicated a causal link between genetically determined folate deficiency and hypertension. In contrast, higher folate levels appeared to protect against elevated blood pressure and hypertension. 

Quatrefolic^® improves folate status and may play a protective role in blood pressure regulation and in the management of hypertension.