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Neuroepigenetics and Brain Aging: The Role of B Vitamins and SAMe
13 February 2026
Nutrition Insight published this video interview with Dr. Andrea Fuso, Professor of Neuroepigenetics and long-term research partner, who explores the role of B vitamins and S-Adenosyl-L-methionine (SAMe) in brain health, focusing on aging and cognitive decline.
Brain function is strongly influenced by one-carbon metabolism, a biochemical process involving B vitamins, such as Quatrefolic®, and S-adenosyl-L-methionine (SAMe). This pathway plays a central role in DNA methylation, an epigenetic mechanism that regulates gene expression and neurotransmitter synthesis.
Disruption of one-carbon metabolism can impair these processes, potentially impacting gene regulation and the production of chemical messengers in the brain.
One-Carbon Metabolism and Age-Related Cognitive Decline
DNA methylation patterns change with age, and maintaining proper methylation is vital for supporting neuronal health and cognitive function. According to Dr. Fuso, supporting efficient one-carbon metabolism may help safeguard the brain from age-related cognitive decline and lower the risk of neurodegenerative diseases such as dementia.
Nutrition, especially vitamin B9 such as Quatrefolic®, appears to be a factor that can affect epigenetic mechanisms involved in brain aging.
Quatrefolic® and SAMe to Support Optimal Methylation
Within this metabolic network, B vitamins serve as essential cofactors that support methylation reactions. SAMe, produced through this pathway, directly contributes to DNA methylation. In this context, the use of bioactive folate forms, such as Quatrefolic®, supports optimal methylation due to its rapid availability for metabolic processes.
Overall, the video highlights epigenetics as a key link between nutrition and cognitive aging, suggesting that adequate intake of Quatrefolic® and SAMe may help maintain brain health over time.
