News
High Folate Intake Linked to Lower Risk of Metabolic Syndrome
7 August 2025
A groundbreaking longitudinal study has revealed a strong link between higher folate intake and a significantly reduced risk of metabolic syndrome (MetS), underscoring the crucial role of B9 vitamins, such as Quatrefolic®, in long-term metabolic health.
Published in JAMA Open Network, the study followed more than 4,400 U.S. adults over 30 years as part of the Coronary Artery Risk Development in Young Adults (CARDIA) study.
The researchers found that participants with sufficient folate intake were 61% less likely to develop MetS—a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
Folate, a water-soluble B vitamin found naturally in foods or as folic acid in supplements, was the only nutrient among the B vitamins studied that was inversely associated with all components of MetS. These include abdominal obesity, high blood pressure, insulin resistance, elevated triglycerides, and low HDL cholesterol.
Biological Mechanisms and Health Implications
Folate and other B vitamins are essential in DNA synthesis and methylation, vital for cellular function and repair. Insufficient intake may contribute to metabolic disturbances such as adiposity, dyslipidemia, endothelial dysfunction, and insulin resistance—all key contributors to MetS.
This study is the first to establish a direct link between serum B9 vitamin levels and the long-term risk of developing metabolic syndrome, marking a significant step forward in nutritional epidemiology.
Quatrefolic® can guarantee the right folate level as part of a comprehensive strategy to reduce the risk of metabolic syndrome.
