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Can Active Folate Help Manage Glycemic Problems?
6 November 2024
Prediabetes and diabetes mellitus are increasingly pressing public health issues, with their prevalence rising globally. Emerging evidence suggests that healthy lifestyle choices for insulin resistance syndrome may be therapeutic and preventive.
Type 2 Diabetes Mellitus (T2DM) is now considered a major risk factor for heart disease. Nearly 80% of deaths in people with diabetes are caused by diabetes-related cardiovascular complications.
The increased risk of heart disease in those with type 2 diabetes is linked to high levels of homocysteine, a compound that can promote inflammation in blood vessels and increase the development of atherosclerosis.
The role of active folate in T2DM
Folate deficiency contributes to elevated homocysteine concentrations, a recognised risk factor for cardiovascular disease and T2DM development.
A meta-analysis published in 2013 investigated the associations of MTHFR-linked homocysteine and T2DM. It provided evidence that the polymorphic TT genotype of MTHFR C677T contributes to susceptibility to T2DM and supports the hypothesis that elevated homocysteine is causally related to increased risk of T2DM.
Quatrefolic®, the active form 5-MTHF, bypasses the MTHFR polymorphism and normalises homocysteine plasma levels.
This points to a possible role for active folate in deterring the development of type 2 diabetes mellitus and mitigating some of the associated diabetic complications.
Diabetes Can Lead to Serious Health Issues
Uncontrolled high blood sugar levels associated with diabetes can cause damage to various organs and lead to chronic health problems.
This includes obesity, heart disease, vision problems, kidney issues, abnormal cholesterol levels, and high blood pressure.
The antioxidant and anti-inflammatory properties of folate, such as Quatrefolic®, can contribute to combating inflammation and the vicious cycle of T2DM-related disease aggravation.
Specifically, active folate can promote micro-vessel (diabetic retinopathy) and nerve growth (diabetic polyneuropathy).
Download our brochure to know more about Active Folate and Glucose Metabolism.
